Just a thought I’ve been pondering for the last year and a half.
Are we treating autoimmune disease at the wrong point of the disease process?
The treatment for the heavy duty (life threatening) autoimmune diseases involves beating down the adaptive immune system (B and T cells) with chemotherapy, biologics, immune suppressing drugs, and steroids. By doing this we bring a lot of risk into the mix and often the risk of treatment for the disease is on par with the risk of the disease itself.
The thoughts that have been swirling in my head, particularly last year while I fought with insurance and had to wait way too long to get my treatment (a treatment that costs over $12,000 and is the ONLY available treatment for me to stop a major flare – and keep in mind that a flare with Wegener’s is not what other people with autoimmune disease describe a flare as – with Wegener’s a flare is systemic, and can turn deadly within days, it’s not sore joints, or ‘I’m not feeling well today’ kind of thing.) On my last flare I got the usual granulomas throughout my lungs (scarring that litters the lungs and in my first round was misdiagnosed as terminal lung cancer) but I also had a few perforating lesions in my lungs (holes – one of them 3cm in diameter) and then just to add some fun to the game, I got significant Pulmonary Embolism that littered my lungs with blood clots. There wasn’t a lot of room for oxygen in my lungs last year, so I sat around a lot, sucking on oxygen, and thinking about solutions.
This is when I thought about the innate immune system. This is our first line of defence. This is where things get messed up in the first place, and we are not looking at what aspect of this initial response needs a fix. It could be the chemical messages that cells leave behind for the immune system to trigger a response. It could be those epithelial cells that are reading the mail all wrong. There are so very many steps that take place before our adaptive immune system comes into play, and eventually gets punished by chemo, ablated by biologics, and beaten down by pred. But the adaptive immune system is a player that becomes involved long after the initial onset of things going wrong. Also by ablating the B cells, as is done with the biologics, we are destroying all of our history of gathering immunity. All of our vaccines gone. All of our childhood disease history and adaptation, gone. After a treatment with biologics, the patient is essentially a newborn baby with about 6-8 months of waiting for the bone marrow to just even produce a batch of new B-cells (now with no memory of your life’s accumulation of immunity.) We are like the aliens in that Tom Cruise move “War of the Worlds”. All you gotta do is sneeze on us, and poof, you win.
Below are some questions I posed using muscle testing to distinguish truth from falsehood in my assertions. (If you want to know more, you can grab any book by Dr. David R. Hawkins and read up on his gift to humanity.)
The current treatment paradigm for autoimmune disease is on the right track.
Treating the adaptive immune system using immune surpassing drugs is the most efficient way to treat autoimmune disease.
There is a cure for autoimmune disease.
Looking for answers in the innate immune response is a more viable treatment option. True
Neutrophils are part of the problem.
Examining the process of chemotaxis would lead in a direction of new treatment and discoveries.
It is possible to direct chemotaxis in a way as to not compromise overall health risks. True
Endothelial disfunction is a first step in autoimmune disease process.
Pathology in endothelial cells is a first step in autoimmune disease.
A positive finding in endothelial cell pathology affects autoimmune disease, heart and stroke, cancer, and mental health.
Autoimmune disease, heart and stroke, mental health and cancer are related in etiological manifestation.
Autoimmune disease is related to excessive or prolonged permeability of the endothelial monolayer.
There is a connection between vascular endothelial cell, neutrophil recruitment and hormone trafficking as part of the onset of autoimmune disease.
The answer to autoimmune disease lies in vascular endothelial cells.
Soft True (a little weaker than the others)
The answer to autoimmune disease lies in lymphatic endothelial cells.
The respiratory epithelium is the underlying problem with Wegener’s Granulomatosis. True
There is a way to improve respiratory epithelium function without the use of immune suppressing drugs.
Simple epithelial tissue abnormalities are the problem behind AI disease.
IL-8 (interluken-8) protein (chemokine) disfunction is the trigger that sets off autoimmune disease.
Soft True (again weaker than the other muscle test responses, but still not the same weakness as False.)
IL-8 disfunction can be repaired using genetic manipulation.
Decreasing glucose intake will alter the chemotaxis that gets the neutrophils going.
Sugar comes into play with the question near the end of my query. Maybe the thousand(s) fold increase of sugar intake in our population (from the perspective of our evolution) could be triggering the mixed messages during chemotaxis. After all watch your kid trying to communicate with you after a slurpee or a hand full of jelly beans. It’s never good. It’s always chaotic, and often loud and nonsensical. That is autoimmune disease.
I sent this idea out to Dr. Bruce Lipton last year when I was stuck in sick-world limbo, but I never got a response from him. It’s ok though, we all ignore some emails, so I can’t hold it against him. Can’t judge someone for stuff you yourself do. Someday we’ll change our sights. Someday autoimmune diseases research will save not only autoimmune disease patients but patients with cancer, AIDS, mental health, and heart and stroke diseases, as all of these are associated with an immune system misfire. Someday we will all be healthy and productive and in the sci-fi book I’m writing on this subject, I have figured out the answer, and with that answer come some added features we couldn’t have even dreamed of. But for that, you have to wait and read the book.